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Anticuerpos Anticolinérgicos Muscarínicos en el Síndrome de Sjögren by Enri Santiago Borda and Daniela Passafaro (2012, Trade Paperback)

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Este trabajo muestra la relación entre los anticuerpos (Ac) séricos anti receptor colinérgico muscarínico (mAChR) M3 (IgG anti-M3) glandular, el desarrollo de la inflamación y la disfunción secretoria. Por ELISA establecimos que la IgG anti-M3 de los pacientes con SSp interaccionó con los mAChR M3 incrementando la producción de PGE2, la cual activó a la PLC con incremento de InsP y aumento del Ca2+ citoplasmático. La CaM estimuló a la ONSi incrementando el GMPc. La activación de PKC provocó una disminución en la secreción de mucina dependiente de la activación del receptor EP1. El aumento en la producción de PGE2 generó un aumento del AMPc y una mayor actividad de MMP-3. Por PCR determinamos que el anticuerpo incrementó la expresión génica de ONSi y COX-2. La IgG anti-M3 demostró también la capacidad para interferir con la acción de la pilocarpina sobre la actividad de la Na+-K+-ATPasa y sobre el eflujo de K+, alterando así la secreción acuosa salival. Los resultados indican que los Ac anti-M3 interactuando con los mAChR M3 glandulares, provocan una disfunción del sistema nervioso autónomo parasimpático glandular con inflamación, participando en la etiopatogenia del síndrome.

Product Identifiers

Publisher
Editorial Academica Espanola
ISBN-10
3659003085
ISBN-13
9783659003080
eBay Product ID (ePID)
121920047

Product Key Features

Author
Enri Santiago Borda, Daniela Passafaro
Publication Name
Anticuerpos Anticolinérgicos Muscarínicos EN El Síndrome De Sjögren
Format
Trade Paperback
Language
English
Publication Year
2012
Type
Textbook
Number of Pages
132 Pages

Dimensions

Item Length
9in.
Item Height
0.3in.
Item Width
6in.
Item Weight
7.2 Oz

Additional Product Features

Topic
General
Genre
Medical

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Anticuerpos Anticolinérgicos Muscarínicos en el Síndrome de Sjögren by Enri Santiago Borda and Daniela Passafaro (2012, Trade Paperback)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Study Guides & Test Prep

2018 International Building Code by International Code Council (2017, Paperback, 1st Edition)

US Citizenship Test Study Guide 2019 Ciudadania Americana 2019 En EspaÃ±ol. Spa

English-Spanish First Words Flash Cards by Scholastic (2021, Print, Other)

Where DID Towers Go Evidence of Directed Freeenergy Technology on by Judy VG

Go Math! Ser.: Go Math! : Student Interactive Worktext Grade 7 2018 by HOUGHTON MIFFLIN HARCOURT (2017, Trade Paperback)

Shadows over Stillwater by Kevin Ross (2019, Hardcover)

Eureka Math 2, Learn, 4 Fractional Units, Module 2 by Great Minds (2021, Trade Paperback)

Save on Study Guides & Test Prep

NFPA 70 NEC 2023 National Electrical Code Spiral Bound Soft Cover

Biblia Bilingüe by Rvr 1960 Staff (2010, Imitation Leather, Bilingual edition)

Where Did the Towers Go? Evidence of Directed Free-energy Technology on 9/11

THE INTERLINEAR BIBLE: Hebrew-Greek-English, Hardcover, 2005, BRAND NEW

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