Equate Extra Strength Anti-Itch and Skin Protectant Cream Diphenhydramine HCl 2%, 1 oz, Compare to Extra Strength Benadryl® Cream Active Ingredient. Active Ingredients: This product contains diphenhydramine hydrochloride 2 percent (topical analgesic) and zinc acetate 0.1 percent (skin protectant), which compares to the active ingredients of Extra Strength Benadryl Itch Stopping Cream.