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Current Topics in Microbiology and Immunology Ser.: Protein Complexes That Modify Chromatin by Jerry L. Workman (2012, Trade Paperback)

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Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Awide variety of such com plexes have now been described. Others are more rare and specialized for specific functions at discreet loci.

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An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
3642629091
ISBN-13
9783642629099
eBay Product ID (ePID)
159985382

Product Key Features

Author
Jerry L. Workman
Publication Name
Protein Complexes That Modify Chromatin
Format
Trade Paperback
Language
English
Publication Year
2012
Series
Current Topics in Microbiology and Immunology Ser.
Type
Textbook
Number of Pages
Xi, 298 Pages

Dimensions

Item Length
9.3in
Item Width
6.1in
Item Weight
17.1 Oz

Additional Product Features

Series Volume Number
274
Number of Volumes
1 Vol.
Lc Classification Number
Rb155-155.8
Reviews
From the reviews:"This volume of Current Topics in Microbiology and Immunology entitled 'Protein Complexes that Modify Chromatin' takes the reader on a detailed voyage through chromatin. â€¦ The book is divided into ten chapters, each contributed by experts in the field of chromatin. â€¦ presents a detailed overview of the protein complexes that associates with chromatin. â€¦ is a great reference for researchers who are specifically interested in chromatin and its associated proteins."(Yassmine Akkari, The Journal of the Association of Genetic Technologists, Vol. 30 (1), 2004)"This book provides timely reviews of several protein complexes that regulate gene expression and chromatin dynamics. Examples of such complexes include nucleosome assembly complexes, ATP-dependent chromatin remodeling complexes â€¦ . These chapters will bring experts in the field up to date on several aspects of chromosome biology and will provide an exciting introduction to the field for new chromatin researchers." (Journal of Investigational Allergology & Clinical Immunology, Vol. 13 (3), 2003), From the reviews: "This volume of Current Topics in Microbiology and Immunology entitled 'Protein Complexes that Modify Chromatin' takes the reader on a detailed voyage through chromatin. ... The book is divided into ten chapters, each contributed by experts in the field of chromatin. ... presents a detailed overview of the protein complexes that associates with chromatin. ... is a great reference for researchers who are specifically interested in chromatin and its associated proteins."(Yassmine Akkari, The Journal of the Association of Genetic Technologists, Vol. 30 (1), 2004) "This book provides timely reviews of several protein complexes that regulate gene expression and chromatin dynamics. Examples of such complexes include nucleosome assembly complexes, ATP-dependent chromatin remodeling complexes ... . These chapters will bring experts in the field up to date on several aspects of chromosome biology and will provide an exciting introduction to the field for new chromatin researchers." (Journal of Investigational Allergology & Clinical Immunology, Vol. 13 (3), 2003), From the reviews: "This volume of Current Topics in Microbiology and Immunology entitled 'Protein Complexes that Modify Chromatin' takes the reader on a detailed voyage through chromatin. â€¦ The book is divided into ten chapters, each contributed by experts in the field of chromatin. â€¦ presents a detailed overview of the protein complexes that associates with chromatin. â€¦ is a great reference for researchers who are specifically interested in chromatin and its associated proteins."(Yassmine Akkari, The Journal of the Association of Genetic Technologists, Vol. 30 (1), 2004) "This book provides timely reviews of several protein complexes that regulate gene expression and chromatin dynamics. Examples of such complexes include nucleosome assembly complexes, ATP-dependent chromatin remodeling complexes â€¦ . These chapters will bring experts in the field up to date on several aspects of chromosome biology and will provide an exciting introduction to the field for new chromatin researchers." (Journal of Investigational Allergology & Clinical Immunology, Vol. 13 (3), 2003)
Table of Content
Nucleosome Assembly and Remodeling.- Chromatin Proteins Are Determinants of Centromere Function.- HPI Complexes and Heterochromatin Assembly.- SMC Protein Complexes and the Maintenance of Chromosome Integrity.- Selective Gene Regulation by SWI/SNF-Related Chromatin Remodeling Factors.- The SWI/SNF Family of ATP-Dependent Chromatin Remodelers: Similar Mechanisms for Diverse Functions.- Changing the DNA Landscape: Putting a SPN on Chromatin.- The MYST Family of Histone Acetyltransferases.- N-CoR-HDAC Corepressor Complexes: Roles in Transcriptional Regulation by Nuclear Hormone Receptors.- The NuRD Complex: Linking Histone Modification to Nucleosome Remodeling.
Copyright Date
2003
Topic
Life Sciences / Cell Biology, Life Sciences / Genetics & Genomics, Genetics
Intended Audience
Scholarly & Professional
Illustrated
Yes
Genre
Science, Medical

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Picture 1 of 1

Current Topics in Microbiology and Immunology Ser.: Protein Complexes That Modify Chromatin by Jerry L. Workman (2012, Trade Paperback)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Textbooks

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Diagnostic and Statistical Manual of Mental Disorders : DSM-5-TR by American Psychiatric Association (2022, Hardcover)

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