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Primary Progressive Multiple Sclerosis by M. Filippi (English) Paperback Book - Picture 1 of 1

Topics in Neuroscience Ser.: Primary Progressive Multiple Sclerosis by G. Comi (2012, Trade Paperback)

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Primary Progressive Multiple Sclerosis by M. Filippi, G. Comi. Author M. Filippi, G. Comi. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial.

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"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin- ical trials have excluded PPMS patients on two counts. Clinical worsening devel- ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the -interferons and glatiramer acetate, preliminary, uncontrolled clinical experi- ence suggests that the results may not be dramatic.

Product Identifiers

Publisher
Springer Milan
ISBN-10
8847022363
ISBN-13
9788847022362
eBay Product ID (ePID)
143870054

Product Key Features

Author
G. Comi
Publication Name
Primary Progressive Multiple Sclerosis
Format
Trade Paperback
Language
English
Series
Topics in Neuroscience Ser.
Publication Year
2012
Type
Textbook
Number of Pages
X, 128 Pages

Dimensions

Item Length
9.3in
Item Width
6.1in
Item Weight
8 Oz

Additional Product Features

Number of Volumes
1 Vol.
Lc Classification Number
Rc346-429.2
Table of Content
1 -- Observations from the Natural History Cohort of London, Ontario.- 2 -- Pathology.- 3 -- Immunology.- 4 -- Neurophysiology.- 5 -- Neuropsychology.- 6 -- Overview of Treatment Trials: Early Baseline Clinical and MRI Data of the PROMiSe Trial.- 7 -- Conventional MRI.- 8 -- Magnetization Transfer and Diffusion Tensor Magnetic Resonance Imaging.- 9 -- Proton Magnetic Resonance Spectroscopy.- 10 -- Functional Magnetic Resonance Imaging.- Subjectlndex.
Copyright Date
2002
Topic
Neurology, Radiology, Radiotherapy & Nuclear Medicine
Intended Audience
Scholarly & Professional
Illustrated
Yes
Genre
Medical

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Topics in Neuroscience Ser.: Primary Progressive Multiple Sclerosis by G. Comi (2012, Trade Paperback)

About this product

Product Information

Product Identifiers

Product Key Features

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Additional Product Features

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