Alternate Programmed Cell Death Signaling in Antiviral Host Defense, Hardcove...
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eBay item number:364874769970
Item specifics
- Condition
- Book Title
- Alternate Programmed Cell Death Signaling in Antiviral Host Defen
- ISBN
- 9783031452772
- Publication Year
- 2023
- Series
- Current Topics in Microbiology and Immunology Ser.
- Type
- Textbook
- Format
- Hardcover
- Language
- English
- Publication Name
- Alternate Programmed Cell Death Signaling in Antiviral Host Defense
- Item Length
- 9.3in
- Publisher
- Springer International Publishing A&G
- Item Width
- 6.1in
- Item Weight
- 15.6 Oz
- Number of Pages
- V, 174 Pages
About this product
Product Information
This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV)where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.
Product Identifiers
Publisher
Springer International Publishing A&G
ISBN-10
3031452771
ISBN-13
9783031452772
eBay Product ID (ePID)
15062642092
Product Key Features
Publication Name
Alternate Programmed Cell Death Signaling in Antiviral Host Defense
Format
Hardcover
Language
English
Publication Year
2023
Series
Current Topics in Microbiology and Immunology Ser.
Type
Textbook
Number of Pages
V, 174 Pages
Dimensions
Item Length
9.3in
Item Width
6.1in
Item Weight
15.6 Oz
Additional Product Features
Series Volume Number
442
Number of Volumes
1 Vol.
Lc Classification Number
Qr180-189.5
Table of Content
Programmed Necrosis in Host Defense.- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis.- Pyroptosis in Antiviral Immunity.- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus.- Subversion of Programed Cell Death by Poxviruses.- Cell Killing by Reovirus: Mechanisms and Consequences.- Outcomes of RIP kinase signaling during neuroinvasive viral infection.
Copyright Date
2023
Topic
Life Sciences / Microbiology, Life Sciences / Virology, Immunology, Microbiology
Dewey Decimal
616.9101
Dewey Edition
23
Illustrated
Yes
Genre
Science, Medical
Item description from the seller
Seller assumes all responsibility for this listing.
eBay item number:364874769970
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Item location:
Jessup, Maryland, United States
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