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Brain Fables : The Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them by Alberto Espay and Benjamin Stecher (2020, Trade Paperback)
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Brain Fables : The Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them, Paperback by Espay, Alberto; Stecher, Benjamin, ISBN 1108744621, ISBN-13 9781108744621, Brand New, Free shipping in the US With no biological boundaries between neurodegenerative diseases as defined today, Brain Fables offers a blueprint for precision medicine.
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About this product
Product Identifiers
PublisherCambridge University Press
ISBN-101108744621
ISBN-139781108744621
eBay Product ID (ePID)16038520473
Product Key Features
Number of Pages174 Pages
Publication NameBrain Fables : the Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them
LanguageEnglish
SubjectNeurology, Internal Medicine
Publication Year2020
TypeTextbook
Subject AreaMedical
AuthorAlberto Espay, Benjamin Stecher
FormatTrade Paperback
Dimensions
Item Height0.4 in
Item Weight11.6 Oz
Item Length9.2 in
Item Width6.1 in
Additional Product Features
Intended AudienceTrade
LCCN2020-004122
Dewey Edition23
Reviews'This book attempts to incorporate overarching scientific themes with a detailed overview of pathophysiology and clinical features of Parkinson's disease. The chapters examine clinical features, subtypes and progression of the disease, ways of looking at the disease scientifically, a comparison to oncology, and a review of disease modifying treatments versus symptomatic treatment. The diagrams and tables are outstanding and the production values are excellent. The book, however, is limited by the attempt to tackle big concepts for a more lay public with very technical writing, an unimaginative look at theory and facts, and the distinctly different styles between the two authors.' Rohit Das, Doody's Book Review Service
IllustratedYes
Dewey Decimal616.8
Table Of ContentPreface; Acknowledgements; 1. The shaky six and the 'second reality'; 2. Pieces of a puzzle?; 3. Disease 'redefinition': a tough pill to swallow; 4. Disease subtypes: the promise and the fallacy; 5. Protein paradox; 6. The fault in our models; 7. Biomarkers: the promise and the fallacy; 8. Lessons from oncology; 9. Symptomatic vs. disease-modifying therapies; 10. The hypothesis that refuses to die; 11. Our living dissonance; 12. The scientific and lay narratives; 13. Challenges viewed from afar; 14. The moonshot: population-based studies of aging; 15. Predictions for the 2020s and beyond; Epilogue. 'When will we have a cure for Parkinson's disease?"; Note added at press time; References; Index.
SynopsisFor neurodegenerative diseases such as Parkinson's and Alzheimer's there is no unifying biology, explaining why every attempt to cure them has failed. This book provides a blueprint for a new way of thinking, eliminating misleading diagnostic labels and enabling the development of effective therapies, one biological subtype at a time., An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. This is because diseases such as Parkinson's and Alzheimer's do not exist in biology. Yet, hundreds of clinical trials around the world are examining the potential of single therapies in thousands of people sharing one of these labels. Compounding the problem, these therapies were developed on evidence from models that do not come close to capturing the complexity of these diseases in the affected humans. These practices must end. Brain Fables is a call to refocus on understanding living and aging to create the personalized treatments each affected individual desperately needs.
LC Classification NumberRC365.E87 2020
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