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Intro. to Protein Architecture:T
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eBay item number:182743603202
Item specifics
- Condition
- Good
- Seller Notes
- “Has former owner's name written in first blank page otherwise fine throughout”
- ISBN
- 9780198504740
- Publication Year
- 2000
- Type
- Textbook
- Format
- Trade Paperback
- Language
- English
- Publication Name
- Introduction to Protein Architecture : the Structural Biology of Proteins
- Item Height
- 0.9in
- Item Length
- 9.7in
- Publisher
- Oxford University Press, Incorporated
- Item Width
- 7.4in
- Item Weight
- 35.3 Oz
- Number of Pages
- 360 Pages
About this product
Product Information
Written in a clear and engaging style, and profusely illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins. The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics. Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the very great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines, undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why). To suit the needs of courses, each chapter includes recommended reading, lists of useful web sites, traditional exercises, and a new type of exercise called a weblem, for WEB-based probLEM.
Product Identifiers
Publisher
Oxford University Press, Incorporated
ISBN-10
0198504748
ISBN-13
9780198504740
eBay Product ID (ePID)
1808316
Product Key Features
Publication Name
Introduction to Protein Architecture : the Structural Biology of Proteins
Format
Trade Paperback
Language
English
Publication Year
2000
Type
Textbook
Number of Pages
360 Pages
Dimensions
Item Length
9.7in
Item Height
0.9in
Item Width
7.4in
Item Weight
35.3 Oz
Additional Product Features
Lc Classification Number
Qp551.L4637 2001
Reviews
'superb accompanying computer-generated graphics ... a tour de force in protein structure. The tremendous wealth of bioinformatic references alone constitute an astonishing achievement for Arthur Lesk.'R. Ryan, British Journal of Biomedical Science, 2001; 58:133'an excellent addition for anyone interested in the three-dimensional structure of proteins.'BioEssays 23, 2001'a well-written, well-illustrated, up-to-date, and unusually complete treatment of 3D protein structure.'Biochemistry and Molecular Biology Education 29 (2001)'It is thrilling to read a book that excites with both the way it presents the available information and the elegance with which this book is analysed.'H. Allen O. Hill, professor of bioinorganic chemistry, University of Oxford. Times Higher Education Supplement, 'an excellent addition for anyone interested in the three-dimensional structure of proteins.'BioEssays 23, 2001, 'superb accompanying computer- generated graphics.. a tour de force inprotein structure. The tremendous wealth of bioinformatic references aloneconstitute an astonishing achievement for Arthur Lesk.'R. Ryan, British Journal of Biomedical Science, 2001; 58:133, This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The "frozen music" of biology is clearly presented in beautiful detail. The computer-generated renderings give pause to anyone who wonders what God was up to when She thought about creating life. Proteins, as represented here, are Her finest efforts. Visually stunning is only the most obvious aspect of this amazing introduction to structural genomics (proteinomics): the systematic study of protein structures. This is a serious graduate level textbook. The text should be considered for any introductory graduate level course in biochemistry. Beginning with sound chemical principles, the text lays a solid foundation for the concepts of secondary and tertiary structure within protein. The author builds a superstructure from which to view the motifs of cofactor binding domains and active sites in enzymes., "A text for second- and third-year undergraduate students and beginning post-graduate students in biological and medical science, incorporating an introduction to the use of the Web in bioinformatics. Explains the general characteristics that underlie all structures, functions, and interactions of proteins observed in nature. Emphasis is on protein architecture and the three-dimensional patterns of protein structures, with a wealth of computer-generated color images. Includes exercises, problems, and 'weblems,' designed to give students practice with the tools required for research in the field. The author is affiliated with the University of Cambridge."--SciTech Book News"In An Introduction to Protein Architecture, Arthur Lesk presents an insightful survey of this most fundamental topic. It is particularly timely for a new text on this subject as the current availability of extensive web-based information resources for protein sequences and structures modifies the traditional role for the textbook. Arthur Lesk is one of the pioneers of the analysis of protein structure and its evolution. ... So, needless to say, this book is brilliantly illustrated with an extensive array of large, clear stereo diagrams for the structures or motifs that are described in the text. Moreover, we believe that the use of stereo figures is essential for truly visualizing the complex 3D geometry of proteins. ... [T]his text, written by a leading expert in the field, is to be highly recommended for anyone wishing to learn about protein architecture in the context of the current structure of bioinformatics information resources."--Trends in Biochemical Sciences, 'a well-written, well-illustrated, up-to-date, and unusually completetreatment of 3D protein structure.'Biochemistry and Molecular Biology Education 29 (2001), 'superb accompanying computer-generated graphics ... a tour de force in protein structure. The tremendous wealth of bioinformatic references alone constitute an astonishing achievement for Arthur Lesk.'R. Ryan, British Journal of Biomedical Science, 2001; 58:133, 'a well-written, well-illustrated, up-to-date, and unusually complete treatment of 3D protein structure.'Biochemistry and Molecular Biology Education 29 (2001), 'It is thrilling to read a book that excites with both the way it presents the available information and the elegance with which this book is analysed.'H. Allen O. Hill, professor of bioinorganic chemistry, University of Oxford. Times Higher Education Supplement, "A text for second- and third-year undergraduate students and beginning post-graduate students in biological and medical science, incorporating an introduction to the use of the Web in bioinformatics. Explains the general characteristics that underlie all structures, functions, and interactions of proteins observed in nature. Emphasis is on protein architecture and the three-dimensional patterns of protein structures, with a wealth of computer-generated color images. Includes exercises, problems, and 'weblems,' designed to give students practice with the tools required for research in the field. The author is affiliated with the University of Cambridge."--SciTech Book News "InAn Introduction to Protein Architecture, Arthur Lesk presents an insightful survey of this most fundamental topic. It is particularly timely for a new text on this subject as the current availability of extensive web-based information resources for protein sequences and structures modifies the traditional role for the textbook. Arthur Lesk is one of the pioneers of the analysis of protein structure and its evolution. ... So, needless to say, this book is brilliantly illustrated with an extensive array of large, clear stereo diagrams for the structures or motifs that are described in the text. Moreover, we believe that the use of stereo figures is essential for truly visualizing the complex 3D geometry of proteins. ... [T]his text, written by a leading expert in the field, is to be highly recommended for anyone wishing to learn about protein architecture in the context of the current structure of bioinformatics information resources."--Trends in Biochemical Sciences, It is thrilling to read a book that excites with both the way it presentsthe available information and the elegance with which this book is analysed. H.Allen O. Hill, professor of bioinorganic chemistry, University of Oxford. TimesHigher Education Supplement, 20/04/01, 28., "A text for second- and third-year undergraduate students and beginning post-graduate students in biological and medical science, incorporating an introduction to the use of the Web in bioinformatics. Explains the general characteristics that underlie all structures, functions, and interactions of proteins observed in nature. Emphasis is on protein architecture and the three-dimensional patterns of protein structures, with a wealth of computer-generated color images. Includes exercises, problems, and 'weblems,' designed to give students practice with the tools required for research in the field. The author is affiliated with the University of Cambridge."--SciTech Book News "In An Introduction to Protein Architecture, Arthur Lesk presents an insightful survey of this most fundamental topic. It is particularly timely for a new text on this subject as the current availability of extensive web-based information resources for protein sequences and structures modifies the traditional role for the textbook. Arthur Lesk is one of the pioneers of the analysis of protein structure and its evolution. ... So, needless to say, this book is brilliantly illustrated with an extensive array of large, clear stereo diagrams for the structures or motifs that are described in the text. Moreover, we believe that the use of stereo figures is essential for truly visualizing the complex 3D geometry of proteins. ... [T]his text, written by a leading expert in the field, is to be highly recommended for anyone wishing to learn about protein architecture in the context of the current structure of bioinformatics information resources."--Trends in Biochemical Sciences
Table of Content
Chapter 1: The photosynthetic reaction centre: protein structure in a microcosmThe reaction centre from Rhodopseudomonas viridisConclusionsRecommended reading and referencesExercises and problemsChapter 2: In vivo, in vitro, in silicoWhy study proteins?Protein structure and conformationThe known protein sequencesThe protein data bankThe World-Wide WebSummaryGlossaryUseful Web sitesRecommended reading and referencesExercises, problems and weblemsChapter 3: Pattern and form in protein structureHelices and sheetsThe heirarchical nature of protein architectureAn album of small structuresClassification of protein structuresLoopsProtein-ligand interactionsUseful Web sitesRecommended reading and referencesExercises, problems, and weblemsChapter 4: The varieties of protein structureCatalogues of protein structureThe known structuresalpha-helical proteinsbeta-sheet proteinsalpha + beta proteinsalpha/beta proteinsClosed beta-alpha-beta barrel structuresIrregular structuresConclusionsUseful web sitesRecommended reading and referencesExercises, problems, and weblemsChapter 5: Molecular evolutionEvolution of protein structuresStructural relationships among related moleculesUseful web sitesRecommended reading and referencesExercises, problems, and weblemsChapter 6: Evolution in selected protein familiesEvolution of the globinsEvolution of serine proteinases of the chymotrypsin familyNAD-binding domains of dehydrogenasesUseful web sitesRecommended reading and referencesExercises, problems, and weblemsChapter 7: Some proteins of the immmune systemAntibody structureProteins of the Major Histocompatibility ComplexT cell receptorsUseful web sitesRecommended reading and referencesExercises, problems, and weblemsChapter 8: Conformational changes in proteinsStructural changes arising from change in state of ligationHinge motions in proteinsThe helix interface shear mechanism of conformational changeThe allosteric change in haemoglobinSerpins: SERine Proteinase InhibitorsHigher-level structural changesIndex
Copyright Date
2001
Topic
Life Sciences / Cell Biology, Life Sciences / Biochemistry
Lccn
00-026264
Dewey Decimal
572/.633
Intended Audience
College Audience
Dewey Edition
21
Illustrated
Yes
Genre
Science
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eBay item number:182743603202
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