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Tumor Angiogenesis : Basic Mechanisms and Cancer Therapy by Dieter Marmé (2007, Hardcover)

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Tumor Angiogenesis by Norbert Fusenig, Dieter Marmé. Author Norbert Fusenig, Dieter Marmé. This book is written by internationally renowned experts. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy.

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Product Information

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
354033176x
ISBN-13
9783540331766
eBay Product ID (ePID)
17038405604

Product Key Features

Author
Dieter Marmé
Publication Name
Tumor Angiogenesis : Basic Mechanisms and Cancer Therapy
Format
Hardcover
Language
English
Publication Year
2007
Type
Textbook
Number of Pages
Xviii, 845 Pages

Dimensions

Item Length
11in
Item Height
0.6in
Item Width
8.3in
Item Weight
81.7 Oz

Additional Product Features

Number of Volumes
1 Vol.
Lc Classification Number
Rc254-282
Reviews
From the reviews:"The chapters in Tumor Angiogenesis are divided into four sections â€¦ . Tumor Angiogenesis is an outstanding overview of the basic science and translational aspects of angiogenesis. â€¦ To fully capitalize on antiangiogenic therapy, we must continue to have an open dialogue between basic scientists and clinical investigators. This book will serve that purpose, not only for graduate students and new investigators in the field, but also for experienced investigators." (Lee M. Ellis, The New England Journal of Medicine, May, 2008), From the reviews: "The chapters in Tumor Angiogenesis are divided into four sections â€¦ . Tumor Angiogenesis is an outstanding overview of the basic science and translational aspects of angiogenesis. â€¦ To fully capitalize on antiangiogenic therapy, we must continue to have an open dialogue between basic scientists and clinical investigators. This book will serve that purpose, not only for graduate students and new investigators in the field, but also for experienced investigators." (Lee M. Ellis, The New England Journal of Medicine, May, 2008), From the reviews: "The chapters in Tumor Angiogenesis are divided into four sections ... . Tumor Angiogenesis is an outstanding overview of the basic science and translational aspects of angiogenesis. ... To fully capitalize on antiangiogenic therapy, we must continue to have an open dialogue between basic scientists and clinical investigators. This book will serve that purpose, not only for graduate students and new investigators in the field, but also for experienced investigators." (Lee M. Ellis, The New England Journal of Medicine, May, 2008)
Table of Content
Historical Overview: Tumor angiogenesis: From bench to bedside.- Mechanisms: Vasculogenesis and angiogenesis in development. Guidance of vascular and neuronal network formation. The angiogenic switch in tumorigenesis. Pathophysiology and clinical implications of vascular endothelial growth factor. Regulation of angiogenesis and vascular homeostasis through the Angiopoietin/Tie system. Eph receptors and ephrins: role in vascular development and tumor angiogenesis. The role of the neuropilins and their associated plexin receptors in tumor angiogenesis and tumor progression. PDGF: impact on physiological and tumor angiogenesis. Hypoxia and tumour angiogenesis. Hypoxia and angiogenesis in GBM. Endogenous inhibitors of angiogenesis. Thrombospondins and angiogenesis. Molecular and cellular aspects of heparanase. Vessel maturation and perivascular cells. Adhesion molecules in the vascular cell cross-talk. Homing and differentiation of endothelial progenitor cells. Molecular players in lymphangiogenesis. The relationship between tumors and the lymphatics: consequences for metastasis. Inflammation and angiogenesis: innate immune cells as modulators of tumor vascularization. Arteriovenous malformation in mice and men.- Animal Models and Preclinical Anti-Angiogenic Studies: VEGF antibodies for anti-angiogenic therapy. VEGF receptor tyrosine kinase inhibitors for the treatment of cancer. VEGF receptor antibodies for anti-angiogenic therapy. Angiopoietin-2 antagonists for anti-angiogenic therapy. Anti-angiogenic therapy with thrombospondins. The use of orthotopic models to validate anti-vascular therapies for cancer. Vascular tumor targeting. Molecular imaging of targets and therapeutics in tumor angiogenesis. Imaging of tumor angiogenesis and anti-angiogenesis. Visualization of microcirculation anti-angiogenic tumor therapy. Cellular actions of angiogenesis inhibitors on blood vessels. Anti-angiogenic therapy for normalization of tumor vasculature and microenvironment. Metronomic anti-angiogenic chemotherapy: questions and answers.- Anti-Angiogenic Tumor Therapy in Clinical Studies: Clinical development of Avastin. Clinical development of Sorafenib (BAY 43-9006), a VEGF-R/RAF inhibitor. Clinical development of the VEGFR signalling inhibitor AZD2171. Clinical development of Sunitinib Malate. The EGF(R) and VEGF(R) pathways as combined targets for anti-angiogenesis trials in cancer therapy. Imaging the effect of anti-angiogenic tumor therapy in clinical studies. ZD6474: preclinical and clinical development. Integrins: targets for anti-angiogenic therapy. Thalidomide in multiple myeloma. Surrogate markers of angiogenesis. Vascular disrupting agents in cancer therapy.
Copyright Date
2008
Target Audience
Scholarly & Professional
Topic
Life Sciences / Molecular Biology, Hematology, Oncology, Pharmacology
Illustrated
Yes
Genre
Science, Medical

All listings for this product

item 1 TUMOR ANGIOGENESIS: BASIC MECHANISMS AND CANCER THERAPY By Dieter Marme VG
$117.95
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item 2 Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy by Norbert Fusenig (Engl
$357.73
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Picture 1 of 1

Tumor Angiogenesis : Basic Mechanisms and Cancer Therapy by Dieter Marmé (2007, Hardcover)

About this product

Product Information

Product Identifiers

Product Key Features

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Additional Product Features

All listings for this product

item 1 TUMOR ANGIOGENESIS: BASIC MECHANISMS AND CANCER THERAPY By Dieter Marme VG

item 2 Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy by Norbert Fusenig (Engl

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Designing Data-Intensive Applications : The Big Ideas Behind Reliable, Scalable, and Maintainable Systems by Martin Kleppmann (2017, Trade Paperback)

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