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Estructura y funcion de la fosforilcolina fosfatasa de P. aeruginosa by Domenech Carlos E, Lisa Angela T, Beassoni Paola R (Paperback, 2011)

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About this product

Product Information

Pseudomonas aeruginosa es una bacteria Gram-negativa destacada por su amplia resistencia a antibioticos y la habilidad de causar enfermedades en individuos susceptibles. Los pacientes con fibrosis quistica tienen una particular propension a las infecciones causadas por esta bacteria. P. aeruginosa tiene una remarcada versatilidad metabolica que le permite adaptarse a una gran variedad de nichos ecologicos. Nuestro laboratorio propuso que colina es un factor que favorece la patogenicidad de P. aeruginosa, entre otras cosas, induciendo acetilcolinesterasa, fosfolipasa C (PlcH) y fosforilcolina fosfatasa (PchP). La accion conjunta de PlcH y PchP permite el establecimiento de la infeccion. PchP cataliza la hidrolisis de fosforilcolina en colina mas fosfato inorganico y pertenece a la superfamilia de las haloacido dehalogenasas (HAD). Este libro representa un trabajo de Tesis Doctoral, donde se estudio la estructura y la funcion de PchP con el objeto de conocer las bases estructurales de su mecanismo catalitico tendientes a sentar las bases para el diseno racional de farmacos que permitan contribuir al control de este importante patogeno oportunista.

Product Identifiers

Publisher
Eae Editorial Academia Espanola
ISBN-13
9783845492643
eBay Product ID (ePID)
141557785

Product Key Features

Author
Domenech Carlos E, Lisa Angela T, Beassoni Paola R
Publication Name
Estructura Y Funcion De La Fosforilcolina Fosfatasa Dep. Aeruginosa
Format
Paperback
Language
Spanish
Subject
Chemistry
Publication Year
2011
Type
Textbook
Number of Pages
208 Pages

Dimensions

Item Height
229mm
Item Width
152mm
Item Weight
313g

Additional Product Features

Title_Author
Lisa Angela T, Domenech Carlos E, Beassoni Paola R

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