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Annals of the New York Academy of Sciences Ser.: VIP, PACAP, and Related Peptides : From Gene to Therapy, Volume 1070 by Marc Laburthe (2006, Trade Paperback)

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This volume provides an overview on the biochemistry, physiology, and pharmacology of vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), and related peptides. VIP and PACAP are undoubtedly among the most fascinating neuropeptides ever identified. They belong to the largest family of regulatory peptides, which comprises several other prominent neuroendocrine peptides including secretin (the first peptide hormone that has been identified), glucagon, and growth hormone-releasing hormone. The structural and physiological relationships of these peptides as well as their receptors provide a unique model for investigating the processes of molecular evolution leading to the diversification of multigene families. The primary structures of VIP and PACAP have been remarkably well conserved across vertebrates, suggesting that these peptides must be involved in vital functions throughout the animal kingdom. Indeed, VIP and PACAP appear to be implicated in a large array of physiological processes such as development; growth; endocrine, cardiovascular, respiratory, reproductive and digestive functions; immune responses; and circadian rhythms. There is also clear evidence that VIP and PACAP exert both trophic and antiproliferative effects on normal and tumor cells. The beneficial influence of VIP and PACAP agonists and antagonists in various pathological states including heart failure, ischemia, asthma, impotence, and cancer has motivated the development of novel selective VIP or PACAP ligands that could potentially be used as antihypertensive, neuroprotective, bronchodilatory, vasodilatory, and/or antiproliferative drugs. The occurrence of multiple VIP/PACAP receptor subtypes and splice variants that exhibit tissue-specific expression and possess differential affinity for various ligands generates hopes for the development of new therapeutic agents that could act selectively on the desired target cells. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas . ACADEMY MEMBERS Please contact the New York Academy of Sciences directly to place your order ( www.nyas.org ). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Product Identifiers

Publisher
Wiley & Sons, Incorporated, John
ISBN-10
1573315508
ISBN-13
9781573315500
eBay Product ID (ePID)
52867677

Product Key Features

Author
Marc Laburthe
Publication Name
Vip, Pacap, and Related Peptides : from Gene to Therapy, Volume 1070
Format
Trade Paperback
Language
English
Series
Annals of the New York Academy of Sciences Ser.
Publication Year
2006
Type
Textbook
Number of Pages
500 Pages

Dimensions

Item Length
9.1in
Item Height
1in
Item Width
6.1in
Item Weight
36.9 Oz

Additional Product Features

Series Volume Number
Vol. 1070
Lc Classification Number
Qp552.N39v57 2006
Copyright Date
2006
Topic
Neuroscience, Life Sciences / Cell Biology
Lccn
2006-016389
Intended Audience
Scholarly & Professional
Illustrated
Yes
Genre
Science, Medical

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Picture 1 of 2

Annals of the New York Academy of Sciences Ser.: VIP, PACAP, and Related Peptides : From Gene to Therapy, Volume 1070 by Marc Laburthe (2006, Trade Paperback)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Textbooks

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