Protein targeting is the study of how newly synthesized proteins reach their ultimate destination. Proteins may be targeted into an intracellular organelle such as the nucleus, mitochondria, or rough endoplasmic reticulum, or they may be secreted or taken up by a cell and distributed tospecific locations such as the endosome or lysosome. Small parts of the protein's structure are recognized by intracellular receptors, which direct or 'target' the protein to its destination. Some proteins must cross membranes during this process, and many are subject to modification as they travel.The understanding of protein targeting has many applications including cancer research, the study of diseases that result from faulty targeting, and the genetic manipulation of microorganisms to target useful proteins. This volume summarizes over 20 years of research activity by the scientificcommunity into this exciting and important phenomenon. As such, it will be of value to students and researchers alike.
Product Identifiers
Publisher
Oxford University Press, Incorporated
ISBN-10
0199632170
ISBN-13
9780199632176
eBay Product ID (ePID)
81676
Product Key Features
Author
Olwyn M. R. Westwood, Brian M. Austen
Publication Name
Protein Targeting and Secretion
Format
Uk-Trade PAPER
Language
English
Series
In Focus Ser.
Publication Year
1991
Type
Textbook
Number of Pages
96 Pages
Dimensions
Item Length
9in
Item Height
0.2in
Item Width
6.1in
Item Weight
6.2 Oz
Additional Product Features
Lc Classification Number
Qp551.A97 1991
Reviews
'This excellent little book provides an easy introduction to this fascinating area of cell biology which has developed rapidly in the past decade. The subject-matter is clearly and concisely organised, yet provides the uninitiated reader with a comprehensive overview of the current state ofknowledge in this field.'Times Higher Education Supplement
Table of Content
1. General principles2. Bacterial protein translocation3. Protein translocation at the rough endoplasmic reticulum4. Assembly of membrane proteins5. Protein sorting and maturation6. Import of proteins from the cytosol into subcellular organelles