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Interaction Studies by Sana Shamim (2012, Trade Paperback)

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About this product

Product Information

The book deals with the metal complexes of Azithromycin, a macrolide and gemifloxacin, fourth generation fluoroquinolone antibacterial which were synthesized characterized and their antimicrobial activities against various Gram negatives, Gram positives and antifungal species were analyzed. Interaction of gemifloxacin with co-administered drugs was also studied and for this purpose their methods on RP-HPLC were developed for the first time. To support these findings gemifloxacin derivatives were synthesized and characterized by physicochemical and spectroscopic methods with above mentioned interacting drugs. Gemifloxacin analogues were synthesized with different aromatic and aliphatic amines, amides, carboxylic acid, and phenols. In this work, we focused on C-3 and C-7 positions of gemifloxacin. The target derivatives were characterized by FT-IR, 1HNMR and mass spectrometry. Antimicrobial and antifungal activity of these newly synthesized analogues was also carried out. Enzymatic inhibition activities of all synthesized derivatives were also carried out against two different enzymes including urease, and -chymotrypsin. The test showed low to moderate activity against both enzymes.

Product Identifiers

Publisher
LAP Gmbh & Company KG
ISBN-10
3848442167
ISBN-13
9783848442164
eBay Product ID (ePID)
167904353

Product Key Features

Author
Sana Shamim
Publication Name
Interaction Studies
Format
Trade Paperback
Language
English
Publication Year
2012
Type
Textbook
Number of Pages
260 Pages

Dimensions

Item Length
9in
Item Height
0.6in
Item Width
6in
Item Weight
13.6 Oz

Additional Product Features

Topic
Pharmacology
Genre
Medical

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