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Chemistry and Biochemistry of Oxygen Therapeutics : From Transfusion to Artificial Blood by Stefano Bettati (2011, Hardcover)

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Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen - the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or "blood substitutes") which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in "non-surgical" patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in Î’ thalassemia and sickle cell disease Finally "old"and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storaâ‰¥ proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia - industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.

Product Identifiers

Publisher
Wiley & Sons, Incorporated, John
ISBN-10
0470686685
ISBN-13
9780470686683
eBay Product ID (ePID)
109128802

Product Key Features

Author
Stefano Bettati
Publication Name
Chemistry and Biochemistry of Oxygen Therapeutics : from Transfusion to Artificial Blood
Format
Hardcover
Language
English
Publication Year
2011
Type
Textbook
Number of Pages
466 Pages

Dimensions

Item Length
9.9in
Item Height
1.1in
Item Width
6.8in
Item Weight
33.8 Oz

Additional Product Features

Lc Classification Number
Rm666.O8c44 2011
Copyright Date
2011
Topic
Life Sciences / Biochemistry, Allied Health Services / Respiratory Therapy, Chemistry / Organic
Lccn
2011-014031
Dewey Decimal
615.8/36
Intended Audience
Trade
Dewey Edition
23
Illustrated
Yes
Genre
Science, Medical

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item 1 Chemistry and Biochemistry of Oxygen Therapeutics : From Transfusion to Artif...
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item 3 Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificia
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item 4 Andrea Mozzarelli Chemistry and Biochemistry of Oxygen Therapeutics (Hardback)
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item 5 Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to: New
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Picture 1 of 1

Chemistry and Biochemistry of Oxygen Therapeutics : From Transfusion to Artificial Blood by Stefano Bettati (2011, Hardcover)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

All listings for this product

item 1 Chemistry and Biochemistry of Oxygen Therapeutics : From Transfusion to Artif...

item 2 Chemistry and Biochemistry of Oxygen Therapeutics : From Transfusion to Artif...

item 3 Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificia

item 4 Andrea Mozzarelli Chemistry and Biochemistry of Oxygen Therapeutics (Hardback)

item 5 Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to: New

Best Selling in Textbooks

Diagnostic and Statistical Manual of Mental Disorders DSM-5-TR by American Psychiatric Association (2022, Trade Paperback)

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Designing Data-Intensive Applications : The Big Ideas Behind Reliable, Scalable, and Maintainable Systems by Martin Kleppmann (2017, Trade Paperback)

Research Design : Qualitative, Quantitative, and Mixed Methods Approaches by J. David Creswell and John W. Creswell (2022, Trade Paperback)

Cognitive Behavior Therapy : Basics and Beyond by Judith S. Beck (2020, Hardcover)

Encyclopedia of Counseling : Master Review and Tutorial for the National Counselor Examination, State Counseling Exams, and the Counselor Preparation Comprehensive Examination by Howard Rosenthal (2017, Trade Paperback, Revised edition,New Edition)

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