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eBay item number:
223401291380
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Item specifics
| Condition: | Good
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A book that has been read but is in good condition. Very minimal damage to the cover including scuff marks, but no holes or tears. The dust jacket for hard covers may not be included. Binding has minimal wear. The majority of pages are undamaged with minimal creasing or tearing, minimal pencil underlining of text, no highlighting of text, no writing in margins. No missing pages. See the seller’s listing for full details and description of any imperfections.
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| Seller Notes: | “Former Library book. Shows some signs of wear, and may have some markings on the inside. 100% Money Back Guarantee. Shipped to over one million happy customers.” |
| Format: | Hardcover | Language: | English |
| Publication Year: | 1988 | Special Attributes: | EX-LIBRARY |
| Publisher: | CRC Press LLC | ISBN: |
9780936923062 |
| EAN: |
9780936923062 |
About this product
| Product Information | |
| Acute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models. For each test, applicable U.S. and international guidelines are also presented, and the formulation and selection of vehicles, dosages, and test animals are addressed. | |
| Product Identifiers | |
| Publisher | CRC Press LLC |
| ISBN-10 | 0936923067 |
| ISBN-13 | 9780936923062 |
| eBay Product ID (ePID) | 513745 |
| Product Key Features | |
| Format | Hardcover |
| Publication Year | 1988 |
| Language | English |
| Dimensions | |
| Weight | 34.4 Oz |
| Width | 6.4in. |
| Height | 1.3in. |
| Length | 9.6in. |
| Additional Product Features | |
| Dewey Edition | 19 |
| Table of Content | INTRODUCTION. OLDEST AND MOST COMMON TESTS. QUESTIONS OF RELEVANCE AND SENSITIVITY. DEFINING TEST OBJECTIVES. USE OF SCREENS IN TOXICOLOGICAL RESEARCH: THEORY AND PRACTICE. INNOVATIONS AND ALTERNATIVES: RATIONALE. ACUTE TOXICOLOGY PROGRAM: STUDY DESIGN AND DEVELOPMENT. THE HAZARD/TOXICITY PROFILE. TIER TESTING. BATTERIES. TEST SELECTION AND DESIGN. TESTS FOR DERMAL IRRITATION AND CORROSION. HISTORY AND OVERVIEW. DERMAL IRRITATION. Primary Dermal Irritation (PDI) in Rabbits. Design Alternatives and Innovations. In Vitro Alternatives. DERMAL CORROSIVITY. DESIGN ALTERNATIVES AND INNOVATIONS. PERCUTANEOUS ABSORPTION. OCULAR IRRITATION TESTING. HISTORY OF OCULAR IRRITATION TESTING. ACUTE EYE IRRITATION TESTS IN RABBITS. Adequacy and Limitations of Current In Vivo Methods. PRESCREENS AND IN VIVO ALTERNATIVES. OVERVIEW OF IN VIVO ALTERNATIVES. DERMAL SENSITIZATION. MECHANISMS. OBJECTIVES AND GENERAL FEATURES OF TESTS. HISTORY. BUEHLER TEST. GUINEA PIG MAXIMIZATION TEST (GPMT). GUINEA PIG SPLIT ADJUVANT TEST. MOUSE EAR SWELLING TEST (MEST). TEST SYSTEM MANIPULATION. PRACTICAL PROBLEMS AND SOLUTIONS. POTENCY PREDICTIONS. IN VITRO ALTERNATIVES. PHOTOSENSITIZATION/PHOTOTOXICITY. THEORY, MECHANISMS AND HISTORY. FACTORS INFLUENCING PHOTOTOXICITY/PHOTOSENSITIZATION. PREDICTIVE IN VIVO TESTS FOR PHOTOTOXICITY. PREDICTIVE IN VIVO TESTS FOR PHOTOSENSITIZATION. IN VITRO TEST SYSTEMS. LETHALITY TESTING. HISTORICAL PERSPECTIVE. PROTOCOL DESIGNS. Classical Designs. Dose Probe Designs. Up-and-Down Method. Pyramiding Studies. Limit Tests. Fixed Dose Procedure. Quality Control Screens. USING LETHALITY DATA IN SAFETY ASSESSMENT-THE MLD. ALTERNATIVES TO LETHALITY TESTING. SAFETY CONSIDERATIONS FOR THE ADMINISTRATION OF AGENTS BY THE PARENTERAL ROUTES. PARENTERAL ROUTES AND RATES. Intravenous. Subcutaneous. Intramuscular. Considerations of Bolus vs. Infusion. TEST SYSTEMS. Irritation (IV, IM & SC). Pyrogenicity. Blood Compatibility. IN VITRO ALTERNATIVES. ACUTE SYSTEMIC TOXICITY TESTS. INTRODUCTION. SCREENS. ACUTE SYSTEMIC TOXICITY CHARACTERIZATION. TESTING WITH NONRODENT SPECIES. ACUTE MECHANISTIC STUDIES. ROUTES, FORMULATIONS AND VEHICLES. MECHANISMS OF ABSORPTION AND DISTRIBUTION OF MAJOR AND MINOR ROUTES. COMPARISONS AND CONTRASTS. GAVAGING TECHNIQUE. VEHICLES AND FORMULATION OF MATERIALS. DOSING CALCULATIONS. CONSIDERATIONS SPECIFIC TO ANIMAL TEST MODELS. COMMON MODEL SPECIES AND THEIR CHARACTERISTICS. CROSS SPECIES EXTRAPOLATION. MODEL SELECTION. LIMITATIONS OF MODELS. SUSCEPTIBILITY FACTORS. SPECIES PECULIARITIES. STRAIN DIFFERENCES. ANIMAL CARE, HUSBANDRY & WELFARE. STATISTICAL ANALYSIS FOR ACUTE TOXICOLOGY. BASIC CONCEPTS. SIGNIFICANCE AND ERROR. FUNCTIONS OF STATISTICS. EXPERIMENTAL DESIGN. RANDOMIZATION & TRANSFORMS. TESTING FOR SIGNIFICANCE. REGRESSION AND MODELING. APPLICATIONS IN TOXICOLOGY. SPECIAL CASE OF SCREENING. ACUTE INHALATION. GENERAL PRINCIPLES. BASICS OF RESPIRATORY PHYSIOLOGY. MECHANICS OF EXPOSURE. INHALATION DOSIMETRY OF COMMON SPECIES. COMMON TEST DESIGNS. PROBLEMS AND ISSUES. USE OF AVAILABLE INFORMATION SOURCES. CONSIDERATIONS IN ADOPTING NEW TEST SYSTEMS. VALIDATION OF ALTERNATIVE AND NEW TESTS. SAR MODELS. SAFETY FACTORS, POTENCY PREDICTORS AND PROTECTING SOCIETY. MIXTURES. SPECIAL CASES: Military Agents. Combustion Toxicology. Medical Devices. Polymers-Special Issues. APPENDICES. REGULATORY ACRONYMS. MOVING AVERAGE TABLES. VEHICLES. DEFINITION OF TERMS AND LEXICON OF CLINICAL OBSERVATIONS. INDEX. 1988, ISBN 0-936923-0607. FEATURES: |
| Illustrated | Yes |
| Dewey Decimal | 615/.704/028 |
| Target Audience | Scholarly & Professional |
| Copyright Date | 1988 |
| Author | Shayne C. Gad, Christopher P. Chengelis |
| Lc Classification Number | Ra1199.4.A38g33 1988 |
| Lccn | 88-002295 |
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