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Iron Chelation Therapy by Springer-Verlag New York Inc. (Paperback, 2012)

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About this product

Product Information

Within the last few years, iron research has yielded exciting new insights into the under- standing of rmal iron homeostasis. However, rmal iron physiology offers little protec- tion from the toxic effects of pathological iron accumulation, because nature did t equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cant be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop- ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Product Identifiers

Publisher
Springer-Verlag New York Inc.
ISBN-10
1461351480
ISBN-13
9781461351481
eBay Product ID (ePID)
141447722

Product Key Features

Format
Trade Paperback (US), Paperback
Language
English
Subject
Clinical Medicine: Professional

Dimensions

Weight
552g
Height
254mm
Width
178mm

Additional Product Features

Place of Publication
New York, NY
Spine
15mm
Edited by
Chaim Hershko
Series Part/Volume Number
509
Series Title
Advances in Experimental Medicine and Biology
Content Note
Biography
Date of Publication
01/10/2012
Edition Statement
Softcover Reprint of the Original 1st Ed. 2002
Country of Publication
United States
Genre
Clinical Medicine: Professional

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