Acetylcarnitine (also spelled acetyl l carnitine) and carnitine play several important roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group of acetyl l carnitine is used to form acetyl-CoA, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, acetyl l carnitine serves as an energy reservoir of acetyl groups and both acetylcarnitine and carnitine help improve energy production. The acetyl group of acetyl l carnitine is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps acetyl l carnitine can even act as a neurotransmitter itself.
What you may notice by taking Acetylcarnitine
Those who take carnitine pills notice an increase in physical energy, but not as much mental energy. Acetyl l carnitine has a significantly more immediate and noticeable mental effect than carnitine because it crosses into the brain much better. The mind boosting effect of acetyl l carnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement.
Acetyl l carnitine Dosage
The typical daily dosage for long term use is 100 to 400 mg once a day, preferably in the early part of the day. Side effects of overstimulation and nausea may occur at dosages greater than 500 mg. Even higher doses may cause insomnia. If you happen to feel nausea, next time just take the acetyl-l-carnitine with food or take a lesser dose.
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Potential Acetyl l Carnitine Benefits of according to published studies:
Acetylcarnitine may improve mental fatigue in those who suffer from chronic fatigue syndrome
Patients with multiple sclerosis are helped by acetylcarnitine, which reduces their fatigue.
In aging rats, chronic administration of acetylcarnitine increases cholinergic synaptic transmission and consequently enhances learning capacity. The memory of aging rats is rejuvenated by giving them a combination of acetylcarnitine and lipoic acid.
Acetyl l carnitine is a promising nutrient for those with diabetic neuropathy. This nutrient could be helpful in chemotherapy induced peripheral neuropathy.
May reduce alcohol-induced cellular damage to organs.
May be helpful in geriatric patients with mild depression.
Acetyl l carnitine improves the function of mitochondria, the organelles within cells that are involved in energy production.
Is more effective than tamoxifen in the therapy of acute and early chronic Peyronie's disease.
May help individuals with degenerative cerebellar ataxia.
Acetylcarnitine is suitable for clinical use in the reduction of neuronal death after peripheral nerve trauma.
May be helpful in those with Alzheimer's disease. Acetyl l carnitine protects against amyloid-beta neurotoxicity.
Forms of Acetyl l Carnitine
You may come across other forms of acetyl carnitine such as acetyl l carnitine arginate. I am not certain whether acetyl l carnitine arginate offers any advantages over acetyl carnitine or carnitine. Time will tell.